In a recent discussion, Andrew Aronsohn, MD, associate professor of Medicine at the University of Chicago Medical Center, highlights the need for a streamlined, one-visit “screen and treat” approach to improve care for patients with hepatitis C (HCV)—especially those from vulnerable populations. These patients often face barriers such as homelessness, substance use, and difficulty navigating complex health systems. Dr. Aronsohn emphasizes that each additional step in care increases the risk of losing patients to follow up. To address this, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) have developed an algorithm that enables clinicians to test and initiate HCV treatment during a single visit—an approach supported by evidence from both HCV and human immunodeficiency virus care models.

This updated algorithm outlines specific actions to be taken during the visit: point-of-care HCV RNA testing for rapid diagnosis, immediate medication dispensing for those who test positive, hepatitis B testing, and follow-up HCV RNA testing four weeks after completing therapy to confirm viral clearance. While the model isn’t suitable for every patient, it offers an important tool for clinicians treating high-risk groups. Dr. Aronsohn, who co-chairs the AASLD/IDSA HCV panel, notes that the algorithm is regularly updated to reflect new treatments and populations. Ultimately, the goal is to simplify the care process and increase the number of people cured of a disease that remains deadly despite being highly treatable.

Reference: Parkinson J, Aronsohn A. AASLD/IDSA Develop a New Algorithm for Hepatitis C Point of Care Testing and Treatment. Contagion. Published April 3, 2025. Accessed June 9, 2025. https://www.contagionlive.com/view/aasld-idsa-develop-a-new-algorithm-for-hepatitis-c-point-of-care-testing-and-treatment